Summary

Graduated in Biology from the Autonomous University of Barcelona, and Master in
Management and Planning of R&D, Leonardo has more than 10 years of experience as
a member of the Higher Council for Sciencitic Research (Consejo Superior de
Investigaciones Científicas - CSIC. Has several publications in prestigious

Academic Studies

Patents and utility models



Centro de Patentes de Universidad de Barcelona, 2012.


Management Science and Innovation



IDEC-Universidad Pompeu Fabra, 2014.

Leadership and management of R & D & business I / Patents, intellectual property and technology transfer / Building companies focused on the development of technological / The business plan opportunities in projects R & D & I regulatory and legal aspects / managing international research projects / institutional Leadership and strategy


Degree in Biology.



Universidad Autónoma de Barcelona (2004).

Work Experience

Researcher



4- 2014/Actually HUCA (Hospital Universitario Central de Asturias)

Experimental design, logistics organization, implementation, documentation of research projects. Monitoring tasks and results. Scientific writing. Inmunological diseases Area


Researcher



5- 2007/4- 2014 CSIC-IDIBAPS

Experimental design, logistics organization, implementation, documentation of research projects. Monitoring tasks and results. Scientific writing. Neurodegenerative diseases Area

Research Interests


Molecular Biology
RNA and DNA isolation
Real Time-PCR
Western Blot
Dot Blot
Zymography
Inmunoprecipitation.

Cell Biology
Primary cell cultures
cell lines culture

Inmunologycal techniques
Inmunfluorescent
Immunochemistry

Publications


“Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkB signaling, MAPK, and Jak1/Stat1 pathways”


Gorina R, Font-Nieves M, Márquez-Kisinousky L, Santalucia T, Planas AM.
. Glia 2011.



“Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes”


Font-Nieves M, Sans-Fons MG, Gorina R, Bonfill-Teixidor E, Salas-Pérdomo A, Márquez-Kisinousky L, Santalucia T, Planas AM.

J Biol Chem. 2012.




“IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion”


Perez-de Puig I, Miró F, Salas-Perdomo A, Bonfill-Teixidor E, Ferrer-Ferrer M, Márquez-Kisinousky L, Planas AM.

J Cereb Blood Flow Metab, 2013.




“Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats”



Mireia Dalmases, Marta Torres, Leonardo Marquez-Kisinousky, Isaac Almendros, Anna Planas, Miguel A. Martinez-Garcia, Daniel Navajas, Ramon Farre, Josep M. Montserrat.

Sleep.2014.


Others


“Brain oxidative stress induced by recurrent obstructive apneas: old versus young rats”


M. Dalmases, A. Planas, M. Torres, L. Marquez-Kisinousky, I. Almendros, M.A. Martínez-García, R. Farre, J.M. Montserrat .

7-11 Septiembre European Respiratory Society Annual Congress 2013. Barcelona.





“TLR4 activation in astrocytes generates a proinflammatory environment through MyD88-dependent and independent pathways not involving IFN-β: modulator effects of heparin”


R Gorina, M Font-Nieves, L Márquez-Kisinousky, T Santalucia, AM Planas.
7-11 Marzo 2010. Cajal Winter Conference. Sociedad Española de Neurociencia. Benasque, Huesca.




“Astrocyte TLRR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkB signaling, MAPK and JAK1/STAT1 pathways”


R Gorina, M Font-Nieves, L Márquez-Kisinousky, Tomàs Santalucia, and Anna M. Planas.
18-19 Octubre 2008. Sección Neurobiología Experimental de la Societat Catalana de Biología. Barcelona.




“La señalización por TLR4 activa la vía Jak1/Stat1 a través de NFkB en cultivos de astrocitos: efectos inhibidores de la Heparina”

R Gorina, L Márquez-Kisinousky, Angel Chamarro, AM Planas.
28-29 Octubre 2008. Sección Neurobiología Experimental de la Societat Catalana de Biología. Barcelona.